Patients should be observed closely for hypersensitivity reactions for a minimum of 30 minutes following each IV iron . Markman et al. ESMO is a Swiss-registered not-for-profit organisation. In the majority of ovarian cancer cases, primary management entails surgical staging or cytoreduction, followed by systemic chemotherapy (Ledermann et al., 2013). Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. Compared to women without hypersensitivity reactions, women who experienced hypersensitivity reactions had a significantly greater median cycle number (12 vs. 6, P < 0.001, independent sample t-test) and dose (6,816 vs. 3,844 mg, P < 0.001, independent sample t-test). Oncol. A history of drug or food allergy, the presence of malignant ascites, and the cumulative carboplatin dose are three independent predictive factors of carboplatin hypersensitivity in this survey. Furthermore, patients with carboplatin hypersensitivity had a higher incidence of previous allergic history to other cytotoxic drugs, including gemcitabine, paclitaxel, and doxorubicin, compared to those without (12/75 vs. 30/660, P < 0.001, chi-squared test; Table 7). The cumulative incidence of carboplatin-related hypersensitivity was 2% after 8 cycles, 6% after 14 cycles, 8% after 19 cycles, and 10% after 33 cycles, with a plateau beyond this cycle number (Figure 1A). 18, 615620. Gynecol. Incidence and Management of Olaratumab Infusion-Related Reactions. PH IV/PH FDC SC is standard of care for HER2-positive BC and usually given with chemotherapy, all of which can trigger anaphylaxis/hypersensitivity. 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Clipboard, Search History, and several other advanced features are temporarily unavailable. Allergic and non-allergic ovarian cancer patients treated with carboplatin or carboplatin desensitization presented a similar life expectancy with a non significant advantage for the allergy desensitized patients. During the study period, our institution applied carboplatin (including carboplatin with cyclophosphamide or paclitaxel) as the front-line chemotherapy for women with ovarian, fallopian tube, and primary peritoneal cancer. The ESMOClinical Practice Guidelines(CPGs) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings ofevidence-based medicine. 66, 265267. CA. PMC Oncol. One-fifth of these patients never attempt carboplatin reinfusion, even after only mild hypersensitivity reactions (Gadducci et al., 2008). J. Clin. sharing sensitive information, make sure youre on a federal 2022 Apr 26;14(4):e24515. It would be worthwhile to evaluate the correlation between other HRD genes and carboplatin hypersensitivity. Bethesda, MD 20894, Web Policies J. Gynecol. 28, 33233329. A prospective single-center study. By delivering the target dose of the drug by small incremental doubling doses (Figure 3), the threshold for anaphylaxis is re-established at each step and never reaches that of the initial triggering dose. Oncol. (2003). doi: 10.1006/gyno.2001.6519, Gadducci, A., Tana, R., Teti, G., Zanca, G., Fanucchi, A., and Genazzani, A. R. (2008). official website and that any information you provide is encrypted Supportive and palliative care are areas of high importance in oncology and ESMO published Clinical Practice Guidelines on the management of a variety of issues: Palliative Care in the COVID-19 era, Advanced Care Planning, Anaemia and Iron Deficiency in Patients With Cancer, Anxiety and Depression,Bone Health in Cancer Patients, Cancer Cachexia in Adult Patients, Cancer Pain, Cancer-related Fatigue,Care at the End of Life, Central Venous Access in Oncology, Chemotherapy Extravasation, Constipation in Advanced Cancer, Delirium in Adult Cancer Patients,Diarrhoea in Adult Cancer Patients, Infusion Reactions to Systemic Anticancer TherapyFebrile Neutropaenia, Fertility Preservation and Post-treatment Pregnancies in Post-pubertal Cancer Patients, Management of Breathlessness in Patients with Cancer,Management of Cardiac Disease, Management of Orphan Symptoms, Neurotoxicity,Oral and Gastrointestinal Mucosal Injury, Prevention and Management of Dermatological Toxicities Related to Anticancer Agents, Prevention of Chemotherapy and Radiotherapy-Induced Nausea and Vomiting, Prognostic Evaluation in Advanced Cancer,Role of Patient-reported Outcome Measures, Toxicities from immunotherapy and Venous Thromboembolism in Cancer Patients. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23, Published in 2017 Ann Oncol (2017) 28 (suppl 4): iv100iv118.Authors: S. Rosell, I. Blasco, L. Garca Fabregat, A. Cervantes and K. Jordan. 4 - 9 Without premedication, hypersensitivity reactions (HSRs) occurred in 25%-30% of patients in these studies and clinical development of paclitaxel was consequently delayed. J. Gynecol. (2003) reported that paclitaxel with platinum improves overall survival compared to conventional platinum-based chemotherapy among patients with relapsed platinum-sensitive ovarian cancer. J. Gynecol. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23. 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Abstracts, slide sets and webcasts from ESMO 2017 Congress are now available. (33)]. 57 . Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. doi: 10.1002/cncr.21168, Dizon, D. S., Sabbatini, P. J., Aghajanian, C., Hensley, M. L., and Spriggs, D. R. (2002). Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report. van de Loosdrecht, Arjan A. J. Gynecol. (2010). eCollection 2022. Statistical analyses were performed using the Statistical Package of Social Studies (SPSS) version 17.0 (SPSS, Inc., Chicago, IL) and SAS software version 9.4 (SAS Inc, NC, USA) for Windows. In 74 of the 75 patients, the hypersensitivity reactions subsided within several minutes to several hours after onset, and the patients recovered without any sequelae. Characteristics of the 735 women receiving carboplatin-based chemotherapy. (2003). (2013). HemaSphere 6 (3):p e695, March 2022. Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. The ESMO Expert Consensus Statement series of publications contain recommendations on well-defined, controversial or clinically relevant topics and are produced by 20-40 key experts in the field. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. sharing sensitive information, make sure youre on a federal Markman, M. (2007). doi: 10.1093/annonc/mdy158. Ovarian cancer is the leading cause of death from gynecological malignancies (Chiang et al., 2013), with a 5-year survival rate of 46% in the United States (92% when localized, 73% with regional metastases, and 28% with distant metastases) (Siegel et al., 2016). HHS Vulnerability Disclosure, Help Unable to load your collection due to an error, Unable to load your delegates due to an error. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Zweizig, S., Roman, L. D., and Muderspach, L. I. 66, 730. 2022 Mar 30;9(4):26. doi: 10.3390/medicines9040026. 57, 163167. Here's a summary of the new ESMO guidelines in 5 key areas: . WHIPPANY, N.J., Sept. 1, 2017 /PRNewswire/ -- Bayer will present the latest research from across its growing oncology portfolio at the European Society for Medical Oncology (ESMO) 2017 Congress . Such reactions were scored according to the Common Terminology Criteria for Adverse Events version 4.03, with severity assessed as mild (grades 1 and 2) or severe (grades 3 and 4). See this image and copyright information in PMC. Would you like email updates of new search results? Allergy Asthma Proc (2011) 32(1):79.10.2500/aap.2011.32.3409 Information for media including press accreditation. However, severe carboplatin-related hypersensitivity symptoms can be fatal, as in one of our cases. Cancer 109, 10721078. Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (2017) 8 Pager Instructions Coverage Begins March 1, 2019 Coverage Ends: TBD 1. . doi: 10.1007/s00280-009-1159-6, Iwamoto, T., Hirai, H., Yamaguchi, N., Kobayashi, N., Sugimoto, H., and Tabata, T. (2014). Europes Beating Cancer Plan in 60 minutes, World Cancer Report Updates Learning Platform, ESMO Scale for Clinical Actionability of molecular Targets (ESCAT), Recognition and Status of Medical Oncology, Status of Medical Oncology in Developing Countries, Shortages of Inexpensive, Essential Cancer Medicines, Accessibility and Availability of Medicines, Availability and Accessibility of Biomolecular Technologies in Oncology, CAREFOR, The Clinical Academic Cancer Research Forum, World Health Organization / United Nations, ESMO responses to European Union and Global Public Consultations, ESMO Facebook Roundtable: COVID-19 Vaccines and Cancer Care - The known, the unknown and the unknowable, ESMO Facebook Roundtable: COVID-19 vs Cancer - Reorganising cancer care after the first wave, ESMO Facebook Roundtable: COVID-19 vs Cancer - The future of cancer research, ESMO Facebook Roundtable: COVID-19 vs Cancer - Weighing up risks over time, COVID-19 and cancer care in the ESMO journals. -, Sakaeda T, Kadoyama K, Yabuuchi H, Niijima S, Seki K, Shiraishi Y, et al. Clinical features of hypersensitivity reactions to carboplatin. eCollection 2022. Gynecol. Risk factors for these reactions included advanced disease, serous histological type, malignant ascites, and history of drug allergies. The cumulative incidence of carboplatin-related hypersensitivity reactions dramatically increased with >8 cycles or dose >3,500 mg. Up to 16% of patients with ovarian cancer who undergo treatment with carboplatin-containing regimens experience carboplatin-related hypersensitivity (Markman et al., 1999; Polyzos et al., 2001; Sliesoraitis and Chikhale, 2005). Gynecol. Parmar et al. doi: 10.1200/JOP.18.00761. Tyler T, Schultz A, Venturini A, Giuliano C, Bernareggi A, Spezia R, Voisin D, Stella V. Clin Pharmacol Drug Dev.
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